FILTER All Development Disease Translation
In this Science research article, we describe a critical window of early-life when specific microbes, such as the yeast Candida dubliniensis, stimulate the growth of host insulin-producing cells. Without these important microbial exposures in infancy, mice went on to develop metabolic deficiencies. Furthermore, we found that exposure to C. dubliniensis was sufficient to prevent and reverse diabetes in mice, suggesting we might harness microbial mechanisms to fight or prevent disease in humans someday.
A mechanistic description of the bacterial protein, BefA, and its conserved ability to elicit direct proliferation of beta-cells
One-hundred years ago, the discovery of the hormone insulin by Frederick Banting and Charles Best transformed the prognosis of type 1 diabetes (T1D). Practically overnight, a diagnosis of T1D went from meaning certain suffering and death to being a manageable, albeit difficult, condition that could result in a long and full life.
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